Expression of Siamois and Twin in the blastula Chordin/Noggin signaling center is required for brain formation in Xenopus laevis embryos

@article{Ishibashi2008ExpressionOS,
  title={Expression of Siamois and Twin in the blastula Chordin/Noggin signaling center is required for brain formation in Xenopus laevis embryos},
  author={Hideyuki Ishibashi and Noriko Matsumura and Hiroshi Hanafusa and Kunihiro Matsumoto and Eddy M. De Robertis and Hiroki Kuroda},
  journal={Mechanisms of Development},
  year={2008},
  volume={125},
  pages={58-66}
}
The blastula Chordin- and Noggin-expressing (BCNE) center located in the dorsal animal region of the Xenopus blastula embryo contains both prospective anterior neuroectoderm and Spemann organizer precursor cells. Here we show that, contrary to previous reports, the canonical Wnt target homeobox genes, Double knockdown of these genes using antisense morpholinos in Xenopus laevis blocked head formation, reduced the expression of the other BCNE center genes, upregulated Bmp4 expression, and… CONTINUE READING

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