Expression of Schwann cell and peripheral T-cell activation epitopes in hereditary motor and sensory neuropathy.

@article{Williams1992ExpressionOS,
  title={Expression of Schwann cell and peripheral T-cell activation epitopes in hereditary motor and sensory neuropathy.},
  author={Lowell L. Williams and John T. Kissel and Barry T. Shannon and Francis J. Wright and Jerry R. Mendell},
  journal={Journal of neuroimmunology},
  year={1992},
  volume={36 2-3},
  pages={147-55}
}
To evaluate possible immune-mediated mechanisms in hereditary motor and sensory neuropathy (HMSN-I, Charcot-Marie-Tooth syndrome), we examined class II major histocompatibility complex antigen expression (MHC-II, HLA-DR) in Schwann cells and peripheral lymphocyte T-cell (Ta1, CD26) activation in five unrelated adults with HMSN-I. Evidence of increased activation expression was found in both compartments but the pattern did not suggest a general state of hyperimmunity or appear related to… CONTINUE READING