Expression of SPARC/osteonectin in tissues of bony and cartilaginous vertebrates.

@article{Ringuette1991ExpressionOS,
  title={Expression of SPARC/osteonectin in tissues of bony and cartilaginous vertebrates.},
  author={Maurice J. Ringuette and Sashko Damjanovski and David Wheeler},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  year={1991},
  volume={69 4},
  pages={245-50}
}
To explore the biological functions of SPARC (secreted protein, acidic, rich in cysteine), a Ca(2+)-binding extracellular glycoprotein, we have examined its expression in an evolutionary diverse group of organisms. Similar patterns of SPARC mRNA expression were observed in adult mouse and rat tissues. SPARC transcripts represented 0.0002-0.0025% of the total RNA found in calvarium, lung, brain, and heart, whereas relatively low levels of SPARC RNA were detected in liver and kidney. Within… CONTINUE READING