Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer.

@article{Wu2012ExpressionOS,
  title={Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer.},
  author={Minqing Wu and Weidong Wei and Xiangsheng Xiao and Jiaoli Guo and Xinhua Xie and Lai-sheng Li and Yanan Kong and Ning Lv and Weihua Jia and Yin Zhang and Xiaoming Xie},
  journal={Medical oncology},
  year={2012},
  volume={29 5},
  pages={3240-9}
}
Several researches reported that overexpression of SIRT1 was associated with poor survival in several human cancers. However, some researches reported that SIRT1 had an antitumor potential. The definite role of SIRT1 is not clear now, and few studies have documented the value of SIRT1 in triple-negative breast cancer (TNBC). Therefore, the aim of this study is to evaluate the role of SIRT1 in TNBC and non-TNBC for prognosis. A total of 51 TNBC patients and 83 non-TNBC patients who were… CONTINUE READING

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