Expression of SIP1 is strongly correlated with LDHA and shows a significantly poor outcome in gastric cancer

@article{Sun2015ExpressionOS,
  title={Expression of SIP1 is strongly correlated with LDHA and shows a significantly poor outcome in gastric cancer},
  author={Xuren Sun and Zhe Sun and Zhi Zhu and Chenyan Li and Junyan Zhang and Huimian Xu and Mingjun Sun},
  journal={Tumor Biology},
  year={2015},
  volume={36},
  pages={7521-7530}
}
Smad interacting protein 1 (SIP1) plays an important role in the epithelial-mesenchymal transition (EMT) process by downregulating E-cadherin. Lactate dehydrogenase A (LDHA) is a crucial enzyme that plays an important role in the final step of the Warburg effect by converting pyruvate to lactate irreversibly. EMT and Warburg effect are the hallmarks of advanced gastric cancer progression. Recently, EMT has been thought to be implicated in cancer metabolism. In this study, we want to find… CONTINUE READING

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