Expression of SERCA isoform with faster Ca2+ transport properties improves postischemic cardiac function and Ca2+ handling and decreases myocardial infarction.

@article{Talukder2007ExpressionOS,
  title={Expression of SERCA isoform with faster Ca2+ transport properties improves postischemic cardiac function and Ca2+ handling and decreases myocardial infarction.},
  author={Md. A. H. Talukder and Anuradha Kalyanasundaram and Xikai Zhao and Li Zuo and Poornima Bhupathy and Gopal Jegadeesh Babu and Arturo J. Cardounel and Muthu Periasamy and Jay L. Zweier},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={293 4},
  pages={H2418-28}
}
Myocardial ischemia-reperfusion (I/R) injury is associated with contractile dysfunction, arrhythmias, and myocyte death. Intracellular Ca(2+) overload with reduced activity of sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) is a critical mechanism of this injury. Although upregulation of SERCA function is well documented to improve postischemic cardiac function, there are conflicting reports where pharmacological inhibition of SERCA improved postischemic function. SERCA2a is the primary… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Similar Papers

Loading similar papers…