Expression of SDF-1α and nuclear CXCR4 predicts lymph node metastasis in colorectal cancer

  title={Expression of SDF-1α and nuclear CXCR4 predicts lymph node metastasis in colorectal cancer},
  author={Naoto Yoshitake and Hirokazu Fukui and Hideo Yamagishi and Akira Sekikawa and Shigehiko Fujii and Shuji Tomita and Kimihisa Ichikawa and Johji Imura and Hideyuki Hiraishi and Takahiro Fujimori},
  journal={British Journal of Cancer},
  pages={1682 - 1689}
Although stromal cell-derived factor (SDF)-1α and its receptor CXCR4 are experimentally suggested to be involved in tumorigenicity, the clinicopathological significance of their expression in human disease is not fully understood. We examined SDF-1α and CXCR4 expression in colorectal cancers (CRCs) and their related lymph nodes (LNs), and investigated its relationship to clinicopathological features. Specimens of 60 primary CRCs and 27 related LNs were examined immunohistochemically for not… CONTINUE READING


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