Expression of SDF-1α and nuclear CXCR4 predicts lymph node metastasis in colorectal cancer

@article{Yoshitake2008ExpressionOS,
  title={Expression of SDF-1α and nuclear CXCR4 predicts lymph node metastasis in colorectal cancer},
  author={Naoto Yoshitake and Hirokazu Fukui and Hideo Yamagishi and Akira Sekikawa and Shigehiko Fujii and Shuji Tomita and Kimihisa Ichikawa and Johji Imura and Hideyuki Hiraishi and Takahiro Fujimori},
  journal={British Journal of Cancer},
  year={2008},
  volume={98},
  pages={1682 - 1689}
}
Although stromal cell-derived factor (SDF)-1α and its receptor CXCR4 are experimentally suggested to be involved in tumorigenicity, the clinicopathological significance of their expression in human disease is not fully understood. We examined SDF-1α and CXCR4 expression in colorectal cancers (CRCs) and their related lymph nodes (LNs), and investigated its relationship to clinicopathological features. Specimens of 60 primary CRCs and 27 related LNs were examined immunohistochemically for not… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 61 extracted citations

Role of CXCR4 and SDF1 as prognostic factors for survival and the association with clinicopathology in colorectal cancer: A systematic meta-analysis.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine • 2017

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcome.

Annals of oncology : official journal of the European Society for Medical Oncology • 2004
View 1 Excerpt

Similar Papers

Loading similar papers…