Expression of S1P metabolizing enzymes and receptors correlate with survival time and regulate cell migration in glioblastoma multiforme

@inproceedings{BienMller2016ExpressionOS,
  title={Expression of S1P metabolizing enzymes and receptors correlate with survival time and regulate cell migration in glioblastoma multiforme},
  author={Sandra Bien-M{\"o}ller and Sandra Lange and Tobias Holm and Andreas Boehm and Heiko Paland and Johannes K{\"u}pper and Susann Herzog and Kerstin Weitmann and Christoph Havemann and Silke Vogelgesang and Sascha Marx and Wolfgang Hoffmann and Henry W.S. Schroeder and Bernhard H Rauch},
  booktitle={Oncotarget},
  year={2016}
}
A signaling molecule which is involved in proliferation and migration of malignant cells is the lipid mediator sphingosine-1-phosphate (S1P). There are hints for a potential role of S1P signaling in malignant brain tumors such as glioblastoma multiforme (GBM) which is characterized by a poor prognosis. Therefore, a comprehensive expression analysis of S1P receptors (S1P1-S1P5) and S1P metabolizing enzymes in human GBM (n = 117) compared to healthy brain (n = 10) was performed to evaluate their… CONTINUE READING