Expression of Ro/SS-A antigen in human skin and heart.

  title={Expression of Ro/SS-A antigen in human skin and heart.},
  author={Jian Song Deng and Richard Dennis Sontheimer and James N. Gilliam},
  journal={The Journal of investigative dermatology},
  volume={85 5},
Using human sera monospecific for anti-Ro/SS-A antibodies in an indirect immunofluorescence assay, Ro/SS-A antigen was found to be present in nuclei of human fetal ectodermal cells and newborn epidermal keratinocytes, but not in adult epidermal keratinocytes. After in vitro cultivation, Ro/SS-A antigen was also found in the nuclei of adult skin explant outgrowth cells. The localization of Ro/SS-A in fetal heart could not be precisely determined (possibly nuclear and membrane). Extracts from… CONTINUE READING