Expression of ROCK-1 in human pancreatic cancer: its down-regulation by morpholino oligo antisense can reduce the migration of pancreatic cancer cells in vitro.

@article{Kaneko2002ExpressionOR,
  title={Expression of ROCK-1 in human pancreatic cancer: its down-regulation by morpholino oligo antisense can reduce the migration of pancreatic cancer cells in vitro.},
  author={Kenzo Kaneko and Kennichi Satoh and Atsushi Masamune and Akihiko Satoh and Tooru Shimosegawa},
  journal={Pancreas},
  year={2002},
  volume={24 3},
  pages={251-7}
}
INTRODUCTION Invasion and metastasis of cancer cells require cell motility and adhesion. The small GTPase Rho and one of its effector molecules ROCK regulate cytoskeleton and actomyosin contractility, and play a crucial role in cell adhesion and motility. Results of previous studies showed that the elevated activity of ROCK-1, one of the isomers of ROCK kinases, led to an increase in the activity of invasion and metastasis of cancer cell lines. AIM To investigate the importance of ROCK-1 in… CONTINUE READING

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