[Expression of RAGE in laryngeal squamous cell carcinoma and clinical significance].

Abstract

OBJECTIVE To study the expression and clinical significance of receptor for advanced glycation end products (RAGE) in laryngeal squamous cell carcinoma (LSCC). METHOD immunohistochemical staining was used to detect the expressions of RAGE protein and semiquantitative method of reverse transcriptase polymerase chain reaction (RT-PCR) was used to analyze the expression level of RAGE mRNA in LSCC tissues and laryngeal normal tissues of 37 cases, respectively. RESULT The mRNA and protein expression of RAGE was significantly higher in LSCC than that in normal laryngeal tissues (P < 0.05), correlated with differentiation (P < 0.01), but not with tumor stage and location (P > 0.05). CONCLUSION The expression levels of RAGE were significantly higher in LSCC than these in laryngeal normal tissues, RAGE is involved in differentiation of LSCC.

Cite this paper

@article{Zhang2009ExpressionOR, title={[Expression of RAGE in laryngeal squamous cell carcinoma and clinical significance].}, author={Huiping Zhang and Rong Zhang and Hanjing Shangguan}, journal={Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery}, year={2009}, volume={23 21}, pages={985-8} }