Expression of PTTG (pituitary tumor transforming gene) in esophageal cancer.

  title={Expression of PTTG (pituitary tumor transforming gene) in esophageal cancer.},
  author={Yasuyuki Shibata and Nobuhiro Haruki and Yoshiyuki Kuwabara and Tadashi Nishiwaki and Joji Kato and Noriyuki Shinoda and Atsushi Sato and Masahiro Kimura and Hiroshi Koyama and Tatsuya Toyama and Hideyuki Ishiguro and Junzo Kudo and Yukio Terashita and Shigeru Konishi and Yoshitaka Fujii},
  journal={Japanese journal of clinical oncology},
  volume={32 7},
BACKGROUND Recently, a vertebrate securin [pituitary tumor transforming gene (PTTG) in humans] has been identified that inhibits sister chromatid separation and is involved in malignant transformation and tumorigenesis. Abundance of this protein would disrupt cell division, generate chromosomal instability and thereby increase cell susceptibility to acquisition of further mutations during subsequent division. Esophageal cancer is a disease with poor prognosis with early local invasion and lymph… CONTINUE READING
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( Pttg )

  • X Zhang, GA Horwitz, TR Prezant, A Valentini, M Nakashima, Bronstein
  • 1999

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