Expression of PTEN in the progression of cervical neoplasia and its relation to tumor behavior and angiogenesis in invasive squamous cell carcinoma.

@article{Lee2006ExpressionOP,
  title={Expression of PTEN in the progression of cervical neoplasia and its relation to tumor behavior and angiogenesis in invasive squamous cell carcinoma.},
  author={Ji Shin Lee and Yoo Duk Choi and Jae Hyuk Lee and Jong Hee Nam and Chan Choi and M. C. M. Lee and Chang-Soo Park and Hyung Seok Kim and Kyung Whan Min},
  journal={Journal of surgical oncology},
  year={2006},
  volume={93 3},
  pages={233-40}
}
BACKGROUND AND OBJECTIVES Loss of PTEN expression has been associated with tumor progression and adverse patient outcome. The purpose of this study was to evaluate PTEN expression in the successive steps of progression in cervical neoplasia and to determine its correlation with tumor angiogenesis and clinicopathologic features in squamous cell carcinoma of the uterine cervix. METHODS Immunohistochemical staining with anti-PTEN antibody was performed in a total of 160 patients with 12 normal… CONTINUE READING