Expression of PPARγ and Paraoxonase 2 Correlated with Pseudomonas aeruginosa Infection in Cystic Fibrosis

@inproceedings{Griffin2012ExpressionOP,
  title={Expression of PPARγ and Paraoxonase 2 Correlated with Pseudomonas aeruginosa Infection in Cystic Fibrosis},
  author={Phoebe E. Griffin and Louise F. Roddam and Yvonne C. Belessis and Roxanne E. Strachan and Sean A. Beggs and Adam Jaff{\'e} and Margaret A. Cooley},
  booktitle={PloS one},
  year={2012}
}
The Pseudomonas aeruginosa quorum sensing signal molecule N-3-oxododecanoyl-l-homoserine lactone (3OC(12)HSL) can inhibit function of the mammalian anti-inflammatory transcription factor peroxisome proliferator activated receptor (PPAR)γ, and can be degraded by human paraoxonase (PON)2. Because 3OC(12)HSL is detected in lungs of cystic fibrosis (CF) patients infected with P. aeruginosa, we investigated the relationship between P. aeruginosa infection and gene expression of PPARγ and PON2 in… CONTINUE READING
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