Expression of PE_PGRS 62 protein in Mycobacterium smegmatis decrease mRNA expression of proinflammatory cytokines IL-1β, IL-6 in macrophages

@article{Huang2010ExpressionOP,
  title={Expression of PE_PGRS 62 protein in Mycobacterium smegmatis decrease mRNA expression of proinflammatory cytokines IL-1β, IL-6 in macrophages},
  author={Ying Huang and Yang Wang and Yu Bai and Zhigang G. Wang and Lifeng Yang and Deming Zhao},
  journal={Molecular and Cellular Biochemistry},
  year={2010},
  volume={340},
  pages={223-229}
}
The pathogenesis of tuberculosis causing Mycobacterium bovis is largely due to its successful entry and survival in macrophages. Previous research indicated that mycobacteria-specific PE_PGRS genes code for cell surface proteins which may have role in mediating interactions with macrophages. In this study, we expressed PE_PGRS 62 gene in a non-pathogenic… CONTINUE READING