Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine

@article{Gagnon2009ExpressionOP,
  title={Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine},
  author={Jeffrey Gagnon and Janice Mayne and Majambu Mbikay and J Woulfe and Michel Chr{\'e}tien},
  journal={Regulatory Peptides},
  year={2009},
  volume={152},
  pages={54-60}
}
The family of serine proteases known as the proprotein convertases subtilisin/kexin type (PCSK) is responsible for the cleavage and maturation of many precursor hormones. Over its three successive regions, the duodenum, the jejunum and the ileum, the small intestine (SI) expresses over 40 peptide hormones necessary for normal intestinal physiology. Most of these hormones derive from proteolytic cleavage of their cognate inactive polypeptide precursors. Members of the PCSK family of proteases… CONTINUE READING
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