Corpus ID: 10571482

Expression of Nrf 2 and NQO 1 in human gastric cancer and their clinical significance

  title={Expression of Nrf 2 and NQO 1 in human gastric cancer and their clinical significance},
  author={Lingzhi Peng and Yaoxing Duan and Y. Zhang and D. Zhao and Yanghui Wen and Jibin Yao and M. Da},
Background: Accumulated evidence shows that constitutively high expression of Nuclear factor erythroid 2-related factor 2 (Nrf2) is associated with cancer growth and progression. NAD(P)H: quinone oxidoreductase 1 (NQO1), as a downstream gene of Nrf2, can also play an important role in occurrence and development of malignancy. In this study, we investigated expression of Nrf2 and NQO1 in gastric cancer and its clinical significance. Methods: Nrf2 and NQO1 protein expression were assessed using… Expand

Figures and Tables from this paper


Clinicopathological significance of nuclear factor (erythroid-2)-related factor 2 (Nrf2) expression in gastric cancer
  • 35
  • Highly Influential
  • PDF
Clinical implications of high NQO1 expression in breast cancers
  • 92
NRF2 immunolocalization in human breast cancer patients as a prognostic factor.
  • 49
  • PDF
Nrf2 overexpression predicts prognosis and 5-FU resistance in gastric cancer.
  • 62
  • PDF
Significance of NQO1 overexpression for prognostic evaluation of gastric adenocarcinoma.
  • 34
Prognostic significance of NQO1 expression in intrahepatic cholangiocarcinoma.
  • 23
Immunohistochemical Study of the Nrf2 Pathway in Colorectal Cancer: Nrf2 Expression is Closely Correlated to Keap1 in the Tumor and Bach1 in the Normal Tissue
  • 22
Nuclear Nrf2 expression is related to a poor survival in pancreatic adenocarcinoma.
  • 55
High expression of NQO1 is associated with poor prognosis in serous ovarian carcinoma
  • 40
Correlation of Nrf2, HO-1, and MRP3 in gallbladder cancer and their relationships to clinicopathologic features and survival.
  • 64