Expression of Neurturin, GDNF, and GDNF Family-Receptor mRNA in the Developing and Mature Mouse

  title={Expression of Neurturin, GDNF, and GDNF Family-Receptor mRNA in the Developing and Mature Mouse},
  author={Judith P Golden and Joseph A. Demaro and Patricia A. Osborne and Jeffrey D. Milbrandt and Eugene M. Johnson},
  journal={Experimental Neurology},
The GDNF family of neurotrophic factors currently has four members: neurturin (NRTN), glial cell line-derived neurotrophic factor (GDNF), persephin, and artemin. These proteins are potent survival factors for several populations of central and peripheral neurons. The receptors for these factors are complexes that include the Ret tyrosine kinase receptor and a GPI-linked, ligand-binding component called GDNF family receptor alpha 1-4 (GFRalpha1-4). We have used in situ hybridization to study the… 

GDNF and GFRαs signaling in frog cardiac ganglion

Structural modeling suggests that GDNF is the endogenous ligand for both GFR 1 and GFR 2 in frog, and Xenopus could serve a possible model organism for studying the cross talk between GDNF and its receptors.

GDNF and GFRα co-receptor family in the developing feline gut.

Site-specific gene expression and localization of growth factor ligand receptors RET, GFRα1 and GFRα2 in human adult colon

The distribution and expression pattern of GDNF and NRTN and their corresponding receptors in the human adult enteric nervous system indicate a role of both GFLs not only in development but also in the maintenance of neurons in adulthood.

Evolution of the GDNF Family Ligands and Receptors

The presence of RET- and GFR-like genes in insects suggests that a ProtoGFR and a ProtoRET arose early in the evolution of bilaterian animals, but when the ProtoGFL diverged from existing transforming growth factor (TGFβ)-like proteins remains unclear.

Expression of neurturin, glial cell line-derived neurotrophic factor, and their receptor components in light-induced retinal degeneration.

The present study indicates that the expression of receptors of the GDNF family is independently regulated in normal and light-damaged rat retina, and suggests that the pattern of modulation of these genes during photoreceptor degeneration is determined by the nature of the apoptotic trigger.

GDNF family ligand immunoreactivity in the gut of teleostean fish

The findings suggest that the presence of GFLs in fish gut is not only limited to developmental period, but could be also involved in the enteric physiology of adult species.

Is GAS1 a co-receptor for the GDNF family of ligands?

Neurturin is a neurotrophic factor for penile parasympathetic neurons in adult rat.

Data suggest that NRTN acts as a target-derived survival and/or neuritogenic factor for penile erection-inducing postganglionic neurons.



Expression of neurturin, GDNF, and their receptors in the adult mouse CNS

The pattern of GF factor and receptor expression in the adult brain suggests a role for these factors in maintaining neuronal circuits in the mature CNS.

Expression of GDNF Family Receptor Components during Development: Implications in the Mechanisms of Interaction

There are multiple mechanisms regulating the interaction between Ret and the α-receptors that mediates the effects of GDNF family trophic factors on the survival and differentiation of cells and on neuron–target interactions in the nervous system.

GFRα3 is an orphan member of the GDNF/neurturin/persephin receptor family

A third member of the GF coreceptor family called GFRα3 that is encoded by a gene located on human chromosome 5q31.2–32 is described, which is not expressed in the central nervous system of the developing or adult animal but is highly expressed in several developing and adult sensory and sympathetic ganglia of the peripheral nervous system.

Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase

The cloning of a new GPI-linked receptor termed NTNR-α that is homologous with GDNFR-α and is widely expressed in the nervous system and other tissues is reported, indicating that GDNF and neurturin promote neuronal survival by signalling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI family of receptors that determines ligand specificity.

Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons

The findings indicate GDNF is a new neurotrophic factor for developing peripheral neurons and suggest possible non-neuronal roles for GDNF in the developing reproductive system.

Characterization of a multicomponent receptor for GDNF

It is demonstrated that physiological responses to GDNF require the presence of a novel glycosyl-phosphatidylinositol (GPI)-linked protein (designated GDNFR-α) that is expressed on GDNF-responsive cells and binds GDNF with a high affinity, which supports the hypothesis that GDNF uses a multi-subunit receptor system in which GDN FR-α and Ret function as the ligand-binding and signalling components.

Neurturin and Glial Cell Line-Derived Neurotrophic Factor Receptor-β (GDNFR-β), Novel Proteins Related to GDNF and GDNFR-α with Specific Cellular Patterns of Expression Suggesting Roles in the Developing and Adult Nervous System and in Peripheral Organs

Multiple roles for NTN and GDNFR-β in the developing and adult organism are suggested, suggesting multiple modi operandi of GDNF and NTN in relation to RET and the two binding proteins.