Expression of Na-H exchanger-8 isoform is suppressed in experimental colitis in adult rat: lack of reversibility by dexamethasone.

@article{AlShamali2011ExpressionON,
  title={Expression of Na-H exchanger-8 isoform is suppressed in experimental colitis in adult rat: lack of reversibility by dexamethasone.},
  author={Amna Al-Shamali and I. Khan},
  journal={Scandinavian journal of gastroenterology},
  year={2011},
  volume={46 1},
  pages={20-9}
}
OBJECTIVES Mechanism of the apical transporter Na-H exchanger-8 (NHE-8) regulation was investigated by examining the effects of anti-inflammatory dexamethasone in experimental colitis. In addition, its localization was investigated in the lipid rich membrane domain called membrane rafts. MATERIAL AND METHODS Colitis was induced by trinitrobenzene sulfonic acid (TNBS) and colon segments were removed from 5 day post-TNBS and used to estimate the levels of NHE-8 protein and mRNA using ECL… CONTINUE READING