Expression of NPM-RARα fusion gene in hematopoietic cells confers sensitivity to troglitazone-induced apoptosis

@article{KamelReid2003ExpressionON,
  title={Expression of NPM-RAR$\alpha$ fusion gene in hematopoietic cells confers sensitivity to troglitazone-induced apoptosis},
  author={Suzanne Kamel‐Reid and Tong Tong Zhang and Richard A. Wells},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={6424-6435}
}
We have investigated the effects of acute promyelocytic leukemia (APL) fusion gene NPM-RARα on the function of PPARγ using the monoblastic cell line U937. U937 cells were transduced using a retrovirus carrying NPM-RARα. While treatment with the synthetic PPARγ ligand troglitazone (TG) had no effect on the viability of U937 cells, TG treatment of U937/NPM-RARα cells resulted in a dramatic decrease in cell viability, dependent upon both the concentration of TG and the level of expression of NPM… Expand
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