Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry.

@article{Zhao1998ExpressionON,
  title={Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry.},
  author={Jinhua Zhao and Brian D. Dynlacht and Takeshi Imai and Takaaki Hori and E E Harlow},
  journal={Genes & development},
  year={1998},
  volume={12 4},
  pages={456-61}
}
To understand the mechanisms by which CDKs regulate cell cycle progression, it is necessary to identify and characterize the physiological substrates of these kinases. We have developed a screening method to identify novel CDK substrates. One of the cDNAs identified in the screen is identical to the recently isolated NPAT gene. Here we show that NPAT associates with cyclin E-CDK2 in vivo and can be phosphorylated by this CDK. The protein level of NPAT peaks at the G1/S boundary. Overexpression… CONTINUE READING

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