Expression of Mouse Interleukin-4 by a Recombinant Ectromelia Virus Suppresses Cytolytic Lymphocyte Responses and Overcomes Genetic Resistance to Mousepox

@article{Jackson2001ExpressionOM,
  title={Expression of Mouse Interleukin-4 by a Recombinant Ectromelia Virus Suppresses Cytolytic Lymphocyte Responses and Overcomes Genetic Resistance to Mousepox},
  author={Ronald James Jackson and Alistair J Ramsay and Carina D. Christensen and Sandra Beaton and Diana F. Hall and Ian Allister Ramshaw},
  journal={Journal of Virology},
  year={2001},
  volume={75},
  pages={1205 - 1210}
}
ABSTRACT Genetic resistance to clinical mousepox (ectromelia virus) varies among inbred laboratory mice and is characterized by an effective natural killer (NK) response and the early onset of a strong CD8+ cytotoxic T-lymphocyte (CTL) response in resistant mice. We have investigated the influence of virus-expressed mouse interleukin-4 (IL-4) on the cell-mediated response during infection. It was observed that expression of IL-4 by a thymidine kinase-positive ectromelia virus suppressed… Expand
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