Expression of Mmp-9 and related matrix metalloproteinase genes during axolotl limb regeneration.

@article{Yang1999ExpressionOM,
  title={Expression of Mmp-9 and related matrix metalloproteinase genes during axolotl limb regeneration.},
  author={Eric V. Yang and David M. Gardiner and Marc Carlson and C A Nugas and Susan V. Bryant},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={1999},
  volume={216 1},
  pages={2-9}
}
One of the earliest events in limb regeneration is the extensive remodeling of the extracellular matrix (ECM). Matrix metalloproteinases (MMPs) are a family of matrix degrading enzymes that have been identified in both normal and disease states. Using RT-PCR and cDNA library screening, we have isolated sequences homologous to four different Mmp genes. The spatial and temporal expression of one of these, Mmp-9, has been analyzed during axolotl limb regeneration. Northern blot analysis identifies… CONTINUE READING