Expression of Met protein in thyroid tumours.

  title={Expression of Met protein in thyroid tumours.},
  author={Luigi P. Ruco and Tamara A. Ranalli and Antonella Marzullo and Paolo Bianco and M. Arenas Prat and Paolo Maria Comoglio and Carlo Davide Baroni},
  journal={The Journal of pathology},
  volume={180 3},
Met protein is a transmembrane 190 kD heterodimer with tyrosine kinase activity, encoded by c-MET oncogene. It serves as a high affinity receptor for hepatocyte growth factor (HGF)/scatter factor (SF), a cytokine which stimulates cell proliferation, motility, and invasion. Expression of Met protein was investigated in 116 thyroid tumours using an anti-Met mouse monoclonal antibody (DQ-13) active on paraffin-embedded material. Reactivity for DQ-13 was observed in 77 per cent of papillary… CONTINUE READING
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