Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung.

@article{Groneberg2002ExpressionOM,
  title={Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung.},
  author={David Alexander Groneberg and Paul R Eynott and Tim Oates and Sam L Lim and Reen Wu and Ingemar Carlstedt and Andrew G. Nicholson and Kian Fan Chung},
  journal={Respiratory medicine},
  year={2002},
  volume={96 2},
  pages={
          81-6
        }
}
Hypersecretion of airway mucus is a characteristic feature of chronic airway diseases like cystic fibrosis (CF) and leads via impairment of the muco-ciliary clearance and bacterial superinfection to respiratory failure. The major components of the mucus matrix forming family of mucins in the airways are MUC5AC and MUC5B. To investigate the expression of these glycoproteins in CF, immunohistochemistry was carried out on trachea, bronchi and peripheral lung obtained from CF patients and compared… CONTINUE READING
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