Expression of MUC5AC, an early marker of pancreatobiliary cancer, is regulated by DNA methylation in the distal promoter region in cancer cells.

@article{Yamada2010ExpressionOM,
  title={Expression of MUC5AC, an early marker of pancreatobiliary cancer, is regulated by DNA methylation in the distal promoter region in cancer cells.},
  author={Norishige Yamada and Yukari Nishida and Seiya Yokoyama and Hideaki Tsutsumida and Izumi Houjou and Sho Kitamoto and Masamichi Goto and Michiyo Higashi and Suguru Yonezawa},
  journal={Journal of hepato-biliary-pancreatic sciences},
  year={2010},
  volume={17 6},
  pages={844-54}
}
BACKGROUND AND PURPOSE High de novo expression of MUC5AC (a gastric-type secreted mucin) is observed in many types of pancreatobiliary neoplasms, including precursor lesions. In this study, we show that the DNA methylation pattern is intimately correlated with MUC5AC expression in ten cancer cell lines (breast, lung, pancreas, and colon). METHODS The CpG methylation status of the MUC5AC promoter from -3855 to +321 was mapped using MassARRAY analysis, which utilizes base-specific cleavage of… CONTINUE READING

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