Expression of MHC class I, MHC class II, and cancer germline antigens in neuroblastoma

  title={Expression of MHC class I, MHC class II, and cancer germline antigens in neuroblastoma},
  author={Matthias Woelfl and Achim A. Jungbluth and Federico Garrido and Teresa Cabrera and Sharon Meyen-Southard and Ruediger Spitz and Karen Ernestus and Frank Berthold},
  journal={Cancer Immunology, Immunotherapy},
Background: Neuroblastoma is the most common solid extracranial tumor in childhood, still with poor survival rates for metastatic disease. Neuroblastoma cells are of neuroectodermal origin and express a number of cancer germline (CG) antigens. These CG antigens may represent a potential target for immunotherapy such as peptide-based vaccination strategies. Objective: The purpose of this study was to analyze the presence of MAGE-A1, MAGE-A3/A6, and NY-ESO-1 on an mRNA and protein level and to… CONTINUE READING


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