Expression of MCP-1 by reactive astrocytes in demyelinating multiple sclerosis lesions.

@article{Voorn1999ExpressionOM,
  title={Expression of MCP-1 by reactive astrocytes in demyelinating multiple sclerosis lesions.},
  author={Patrick van der Voorn and Janneke Tekstra and Robert H. J. Beelen and Cornelius P Tensen and P van der Valk and Corline J A de Groot},
  journal={The American journal of pathology},
  year={1999},
  volume={154 1},
  pages={45-51}
}
The pathology of multiple sclerosis (MS) is characterized by breakdown of the blood-brain barrier (BBB), accompanied by infiltration of macrophages and T lymphocytes into the central nervous system (CNS). The migration of these cells into the CNS parenchyma may be partly regulated by chemokines. The aim of this study was therefore to investigate the cellular localization of the potent monocyte- and T-cell-attracting chemokine monocyte chemoattractant protein (MCP)-1 by immunohistochemistry on… CONTINUE READING