Expression of MCAM/MUC18 by human melanoma cells leads to increased tumor growth and metastasis.

@article{Xie1997ExpressionOM,
  title={Expression of MCAM/MUC18 by human melanoma cells leads to increased tumor growth and metastasis.},
  author={Shuping Xie and M R Luca and Suyun Huang and Mordechai Gutman and Reuven Reich and Judith P. Johnson and Menashe M Bar-Eli},
  journal={Cancer research},
  year={1997},
  volume={57 11},
  pages={2295-303}
}
The cell surface adhesion molecule MCAM (MUC18) is strongly expressed by advanced primary and metastatic melanomas but is weaker and less frequent in nevus cells. Previous studies have shown that MCAM expression correlates with tumor thickness and metastatic potential of human melanoma cells in nude mice. To provide direct evidence that MCAM plays a role in tumor growth and metastasis of human melanoma, the nonmetastatic MCAM-negative primary cutaneous melanoma SB-2 cells were transfected with… CONTINUE READING
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