Expression of MAGE genes in transitional-cell carcinomas of the urinary bladder.

  title={Expression of MAGE genes in transitional-cell carcinomas of the urinary bladder.},
  author={J. J. Patard and Francis Brasseur and S Gil-Diez and François Radvanyi and Marie Marchand and Patrice François and A. S. Abi-Aad and Paul van Cangh and Claude Cl{\'e}ment Abbou and Dominique Chopin},
  journal={International journal of cancer},
  volume={64 1},
Human genes MAGE-1 and MAGE-3 code for distinct antigens, which are recognized on melanoma cells by autologous cytolytic T lymphocytes (CTL). These antigens may constitute useful targets for anti-cancer immunotherapy, since no expression of MAGE genes has been observed in normal tissues other than testis. Out of 57 samples of primary transitional-cell carcinomas of the bladder, 12 (21%) expressed MAGE-1 and 20 (35%) expressed MAGE-3. All but one of the tumors expressing MAGE-1 also expressed… CONTINUE READING
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