Expression of MAGE-antigens in normal tissues and cancer.

  title={Expression of MAGE-antigens in normal tissues and cancer.},
  author={Achim A. Jungbluth and Klaus J. Busam and Denise Kolb and Kristin Iversen and Keren A Coplan and Y T Chen and Giulio Cesare Spagnoli and L. John Old},
  journal={International journal of cancer},
  volume={85 4},
The human MAGE gene family encodes products that can be recognized by autologous cytotoxic T cells. Because MAGE genes are silent in most normal tissues except testis but are activated in a variety of neoplastic lesions, MAGE antigens represent ideal targets for immunotherapy. Current knowledge of MAGE gene expression is based primarily on mRNA typing and relatively little is known about MAGE protein expression. Monoclonal antibody (MAb) 57B, originally thought to be specific for MAGE-3, but… CONTINUE READING
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