Expression of MAGE and BAGE genes in Japanese breast cancers.

  title={Expression of MAGE and BAGE genes in Japanese breast cancers.},
  author={Tatsuo Fujie and Masaki Mori and Hiroaki Ueo and Keishi Sugimachi and Tsuyoshi Akiyoshi},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  volume={8 4},
BACKGROUND The MAGE and BAGE genes code for distinct antigens, which are recognized on melanoma cells as well as on other various tumor cells by autologous cytolytic T lymphocytes. These antigens may thus constitute useful targets for specific immunotherapy, since no expression of MAGE or BAGE genes has been recognized in normal tissue except for the testis. PATIENTS AND METHODS We studied the MAGE-1, MAGE-3, and BAGE gene expression observed in 49 Japanese breast cancers. Gene expression was… CONTINUE READING