Expression of Leptin, Leptin Receptor, Adiponectin, and Adiponectin Receptor in Ductal Carcinoma In Situ and Invasive Breast Cancer

@article{Jeong2011ExpressionOL,
  title={Expression of Leptin, Leptin Receptor, Adiponectin, and Adiponectin Receptor in Ductal Carcinoma In Situ and Invasive Breast Cancer},
  author={Y. Jeong and J. Bong and Sung-Hwan Park and Jung-Hye Choi and H. Oh},
  journal={Journal of Breast Cancer},
  year={2011},
  volume={14},
  pages={96 - 103}
}
Purpose Adipocytokines, such as leptin, resistin, and adiponectin, are associated with obesity and breast cancer. Several studies have indicated that adipocytokines may influence tumor growth or differentiation. The aims of this study were to determine the expression of leptin, leptin receptor (ObR), adiponectin and adiponectin receptor (AdipoR) in human breast cancer, to evaluate their prognostic significance in the breast cancer. Methods Specimens from 198 patients with primary breast cancer… Expand
Immunohistochemical analysis of adipokine and adipokine receptor expression in the breast tumor microenvironment: associations of lower leptin receptor expression with estrogen receptor-negative status and triple-negative subtype
TLDR
Lower LEPR IHC expression within the breast tumor microenvironment might contribute mechanistically to inter-individual variation in aggressive breast cancer clinicopathology, particularly ER-negative status and triple-negative subtype. Expand
Adiponectin and adiponectin receptor 1 expression proteins levels are modified in breast cancer in postmenopausal women with obesity
TLDR
It is found that women with overweight or obesity had a lower expression of ADIPOQ and a higher ADIPOR1 expression in breast cancer tissue, when compared with women with a normal BMI. Expand
Immunohistochemical staining of leptin is associated with grade, stage, lymph node involvement, recurrence, and hormone receptor phenotypes in breast cancer
TLDR
The preliminary findings support leptin clinical value in confirming BC diagnosis as well as prognosis and suggest that leptin molecule is an important biomarker that could identify type, grade, stage, lymph node involvement, relapse and prognosis in breast cancer. Expand
Leptin is overexpressed in the tumor microenvironment of obese patients with estrogen receptor positive breast cancer
TLDR
The current study concluded that leptin may enhance breast cancer progression by inducing the expression of JAK/STAT3, ERK1/2 and estrogen pathways in obese patients breast cancer. Expand
Globular adiponectin enhances invasion in human breast cancer cells
TLDR
The results of the present study suggested that a specific AdipoQ isoform may enhance breast cancer invasion, possibly via autophagic induction. Expand
Lack of prognostic significance of adiponectin immunohistochemical expression in patients with triple-negative breast cancer
TLDR
The results suggest that adiponectin immunohistochemical expression is not of prognostic significance in TNBCs, and further studies are warranted to determine the role of this adipokine in breast cancer biology. Expand
Leptin Induces a Proliferative Response in Breast Cancer Cells but Not in Normal Breast Cells
TLDR
Investigation of procarcinogenic potential of leptin evaluated influence of leptin on cell proliferation, cell cycle, apoptosis, and signaling on numerous breast cells lines, including 184B5 normal cells and MCF-7, MDA-MB-231, and T47D cancer cells found that obesity-associated hyperleptinemia may be a breast cancer risk factor. Expand
Tumor expression of adiponectin receptor 2 and lethal prostate cancer.
TLDR
The evidence for the role of AdipoR2 in prostate cancer progression is strengthened as a statistically significant trend is identified for the association between quartile of AdipsiR2 expression and lethal prostate cancer. Expand
Cellular Expression of Cyclooxygenase, Aromatase, Adipokines, Inflammation and Cell Proliferation Markers in Breast Cancer Specimen
TLDR
Examination of tissues adjacent to tumor, tumor itself and compare them with normal or benign breast tissues for a better understanding of breast cancer pathology and future evaluation of therapeutic benefit are focused on. Expand
Esophageal adenocarcinoma and obesity: peritumoral adipose tissue plays a role in lymph node invasion
TLDR
Peritumoral adipose tissue may exert a direct effect on the progression of EAC by secreting depot-specific paracrine factors, and leptin is a key player in this crosstalk. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 37 REFERENCES
Enhanced Expression of Leptin and Leptin Receptor (OB-R) in Human Breast Cancer
TLDR
Leptin may have a promoting effect on the carcinogenesis and metastasis of breast cancer, possibly in an autocrine manner and functional inhibition of leptin may be effective for the prevention and treatment of Breast cancer. Expand
Increased Expression of Leptin and the Leptin Receptor as a Marker of Breast Cancer Progression: Possible Role of Obesity-Related Stimuli
TLDR
Leptin and ObR are overexpressed in breast cancer, possibly due to hypoxia and/ or overexposure of cells to insulin, IGF-I, and/or estradiol. Expand
Influence of insulin resistance on adiponectin receptor expression in breast cancer.
TLDR
A close relationship between the intratumoral insulin signalling system and AdipoR1 but not AdipiR2 expression is proposed as well as different functions of the two adiponectin receptors in breast cancer. Expand
Adipocyte fatty acid-binding protein as a novel prognostic factor in obese breast cancer patients
TLDR
It is revealed that high A-FABP serum levels are associated with obesity, breast cancer risk, and adverse tumor characteristics, and adiponectin showed no significant association with breast cancer. Expand
Leptin--a growth factor in normal and malignant breast cells and for normal mammary gland development.
TLDR
Leptin appears to be able to control the proliferation of both normal and malignant breast epithelial cells, and the leptin pathway should be further studied as a target for interventions to treat or prevent breast cancer. Expand
Association of serum adiponectin levels with breast cancer risk.
TLDR
It is suggested that tumors arising in women with the low serum adiponectin levels are more likely to show a biologically aggressive phenotype and that the association between obesity and breast cancer risk might be partly explained by adiponECTin. Expand
Tissue levels of adiponectin in breast cancer patients
TLDR
The results suggest that the high tissue adiponectin levels significantly detected in breast cancer patients and associated with an increased risk for breast cancer. Expand
Adiponectin and breast cancer risk.
TLDR
Despite a fairly robust inverse association of adiponectin with breast cancer risk among postmenopausal women, no such significant association between adiponECTin and breast cancer was found among pre menopausal women. Expand
Antiproliferative effect of adiponectin on MCF7 breast cancer cells: a potential hormonal link between obesity and cancer.
TLDR
It is concluded that adiponectin inhibits proliferation but causes no apoptosis of MCF7 breast cancer cells, suggesting that adip onectin may represent a direct hormonal link between obesity and cancer. Expand
Adiponectin mediates an antiproliferative response in human MDA-MB 231 breast cancer cells.
TLDR
The results strongly suggest that the two adipokines should be considered as i) additional factors of breast cancer risk, and ii) may therefore be potential targets in breast cancer therapy. Expand
...
1
2
3
4
...