Expression of Lea in gastric cancer cell lines depends on FUT3 expression regulated by promoter methylation.

@article{Serpa2006ExpressionOL,
  title={Expression of Lea in gastric cancer cell lines depends on FUT3 expression regulated by promoter methylation.},
  author={Jacinta Serpa and Patricia Lagun Mesquita and Nuno Mendes and Carla Sofia Oliveira and Raquel Almeida and Filipe Santos-Silva and Celso A Reis and Jacques Lependu and Leonor David},
  journal={Cancer letters},
  year={2006},
  volume={242 2},
  pages={191-7}
}
Aberrant expression of Lewis antigens has been demonstrated in gastric lesions, namely gastritis, intestinal metaplasia (IM) and gastric carcinoma (GC), and can be partly due to overexpression of the Lewis (FUT3) enzyme. Our aim was to evaluate the role of promoter methylation in FUT3 and Le(a) expression in gastric carcinoma cell lines. MKN45 cell line showed low amounts of Le(a), in the absence of FUT3; GP220 expressed high levels of Le(a) and FUT3. After 5aza-2'deoxycytidine MKN45 showed… CONTINUE READING