Expression of LRIG1, a Negative Regulator of EGFR, Is Dynamically Altered during Different Stages of Gastric Carcinogenesis.

@article{Yu2018ExpressionOL,
  title={Expression of LRIG1, a Negative Regulator of EGFR, Is Dynamically Altered during Different Stages of Gastric Carcinogenesis.},
  author={Sungsook Yu and Mijeong Yang and Kyung-Min Lim and Yejin Cho and Hyunji Kim and Keunwook Lee and Sang-Ho Jeong and Robert J Coffey and James R Goldenring and Ki Taek Nam},
  journal={The American journal of pathology},
  year={2018},
  volume={188 12},
  pages={
          2912-2923
        }
}
Leucine-rich repeats and immunoglobulin-like domains (LRIG)-1 is a transmembrane protein that antagonizes epidermal growth factor receptor signaling in epithelial tissues. LRIG1 is down-regulated in various epithelial cancers, including bladder, breast, and colorectal cancer, suggesting that it functions as a tumor suppressor. However, its role in gastric carcinogenesis is not well understood. Here, we investigated the changes in LRIG1 expression during the stages of gastric cancer. We used a… CONTINUE READING
BETA