Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies.

@article{Shen1994ExpressionOL,
  title={Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies.},
  author={Michael M Shen and Radek C. Skoda and Robert Cardiff and Juanita Campos-Torres and Philip Leder and David M Ornitz},
  journal={The EMBO journal},
  year={1994},
  volume={13 6},
  pages={1375-85}
}
Leukemia inhibitory factor (LIF) is a cytokine involved in embryonic and hematopoietic development. To investigate the effects of LIF on the lymphoid system, we generated a line of transgenic mice that expresses diffusible LIF protein specifically in T cells. These mice display two categories of phenotype that were not previously attributed to LIF overexpression. First, they display B cell hyperplasia, polyclonal hypergammaglobulinemia and mesangial proliferative glomerulonephritis, defects… CONTINUE READING
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