Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma.

@article{Hoang2004ExpressionOL,
  title={Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma.},
  author={Bang H. Hoang and Tadahiko Kubo and John H. Healey and Rebecca Sowers and BethAnne Mazza and Rui Yang and Andrew G. Huvos and Paul A. Meyers and Richard Greg Gorlick},
  journal={International journal of cancer},
  year={2004},
  volume={109 1},
  pages={106-11}
}
The Wingless-type (Wnt) family of proteins and its coreceptor LRP5 have recently been implicated in human skeletal development. Wnt pathway modulates cell fate and cell proliferation during embryonic development and carcinogenesis through activation of receptor-mediated signaling. Osteosarcoma (OS) is a bone-forming tumor of mesenchymal origin whose growth control has been linked to autocrine or paracrine stimulation by several growth factor families. We examined 4 OS cell lines for WNT1, WNT4… CONTINUE READING

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