Expression of KiSS-1, a metastasis suppressor gene, in trophoblast giant cells of the rat placenta.

@article{Terao2004ExpressionOK,
  title={Expression of KiSS-1, a metastasis suppressor gene, in trophoblast giant cells of the rat placenta.},
  author={Yasuko Terao and Satoshi Kumano and Yoshihiro Takatsu and Masahiko Hattori and Atsushi Nishimura and Tetsuya Ohtaki and Yasushi Shintani},
  journal={Biochimica et biophysica acta},
  year={2004},
  volume={1678 2-3},
  pages={102-10}
}
Metastin is encoded by a putative human metastasis suppressor gene KiSS-1, and is the cognate ligand of a G-protein-coupled receptor designated OT7T175. To study the physiological function(s) of metastin, we cloned rat and mouse KiSS-1 cDNAs both encoding 130-amino acid KiSS-1 proteins. Sequence analysis suggested that processing of the rat and mouse KiSS-1 proteins produces 52-amino-acid peptides, each with an amidated carboxyl terminal and with a single possible disulfide bond, corresponding… CONTINUE READING