Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model.

Abstract

An acquired somatic mutation, Jak2V617F, was recently discovered in most patients with polycythemia vera (PV), chronic idiopathic myelofibrosis (CIMF), and essential thrombocythemia (ET). To investigate the role of this mutation in vivo, we transplanted bone marrow (BM) transduced with a retrovirus expressing either Jak2 wild-type (wt) or Jak2V617F into… (More)
DOI: 10.1182/blood-2005-12-4824

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@article{Wernig2006ExpressionOJ, title={Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model.}, author={Gerlinde Wernig and Thomas Mercher and Rachel O. Okabe and Ross L. Levine and Benjamin Howard Lee and Dwight Gary Gilliland}, journal={Blood}, year={2006}, volume={107 11}, pages={4274-81} }