Expression of IgD by murine lymphocytes. Loss of surface IgD indicates maturation of memory B cells

@article{Black1978ExpressionOI,
  title={Expression of IgD by murine lymphocytes. Loss of surface IgD indicates maturation of memory B cells},
  author={Samuel James Black and Wessel van der Loo and Michael R. Loken and Leonard A. Herzenberg},
  journal={The Journal of Experimental Medicine},
  year={1978},
  volume={147},
  pages={984 - 996}
}
B lymphocytes capable of generating primary IgM and IgG plaque-forming cells (PFC) responses to burro erythrocytes have surface IgD, as do primary IgM PFC. IgG memroy cells arising after one injection of antigen are divided into two groups, one of which expresses surface IgD while the other has no detectable membrane IgD. PFC generated from the IgG memory cells lacking surface IgD show a higher average avidity than those arising from IgD-positive IgG memory cells, indicating that mature IgG… CONTINUE READING
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Mouse immunoglobulin allotypes: on Jauary 10, 2018 em .rupss.org D ow nladed fom 9 9 6 EXPRESSION OF IgD BY MURINE LYMPHOCYTES description and specific methodology

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