Expression of Id2 and Id3 mRNA in human lymphocytes.

  title={Expression of Id2 and Id3 mRNA in human lymphocytes.},
  author={Atsushi Ishiguro and Konstantin S. Spirin and Masaaki Shiohara and Andreas R Tobler and John D. Norton and Muriel Rigolet and Toshikazu Shimbo and H Phillip Koeffler},
  journal={Leukemia research},
  volume={19 12},
Helix-loop-helix (HLH) transcription factors are involved in cellular growth and differentiation. The Id (inhibitor of DNA binding and differentiation) HLH proteins, in a dominantly negative fashion, regulate transcriptional activities of basic HLH proteins. We examined by northern hybridization the expression of Id2 and Id3 mRNA in human leukemia/lymphoma lines and patient samples, as well as resting and activated normal human lymphocytes from peripheral blood (PBL). The Id2 mRNA was… CONTINUE READING


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