Expression of Id helix-loop-helix proteins in colorectal adenocarcinoma correlates with p53 expression and mitotic index.

@article{Wilson2001ExpressionOI,
  title={Expression of Id helix-loop-helix proteins in colorectal adenocarcinoma correlates with p53 expression and mitotic index.},
  author={J. Warren Wilson and Richard W. Deed and Takamitsu Inoue and Manuela Balzi and A. Becciolini and Paola Faraoni and Christopher S. Potten and John D. Norton},
  journal={Cancer research},
  year={2001},
  volume={61 24},
  pages={
          8803-10
        }
}
Id helix-loop-helix (HLH) proteins function as regulators of cell growth and differentiation and when overexpressed can induce malignant transformation. In a series of 34 cases of primary human colorectal adenocarcinoma, immunoreactivity for Id1, Id2, and Id3 was found to be significantly elevated in tumor compared with normal mucosa (P = 0.001 for Id1 and Id2; P = 0.002 for Id3). No elevation of Id expression was observed in 17 cases of adenoma. Expression of Id1 and to a lesser extent of Id2… CONTINUE READING

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