Expression of IL-6 mRNA in normal rat and human pituitaries and in human pituitary adenomas.

@article{Velkeniers1994ExpressionOI,
  title={Expression of IL-6 mRNA in normal rat and human pituitaries and in human pituitary adenomas.},
  author={Brigitte Velkeniers and Professor D. Vergani and Jacqueline Trouillas and J D'haens and Robert J. Hooghe and Elizabeth L Hooghe-Peters},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={1994},
  volume={42 1},
  pages={67-76}
}
Cells expressing IL-6 mRNA were detected by in situ hybridization in normal pituitaries. In normal untreated rat pituitary the expression was very low. Within hours after IP administration of liposaccharide, IL-6 mRNA accumulated in the anterior lobe of the pituitary. Production of IL-6 was monitored after dissociation and culture of pituitary cells. High levels (8000 pg/ml) were recovered after 72 hr in culture. In normal human pituitaries, less than 1% of cells expressed IL-6 mRNA or IL-6… CONTINUE READING