Expression of IL-6 and IL-6 receptors by circulating clonotypic B cells in multiple myeloma: potential for autocrine and paracrine networks.

@article{Szczepek2001ExpressionOI,
  title={Expression of IL-6 and IL-6 receptors by circulating clonotypic B cells in multiple myeloma: potential for autocrine and paracrine networks.},
  author={Agnieszka J. Szczepek and Andrew R. Belch and Linda M. Pilarski},
  journal={Experimental hematology},
  year={2001},
  volume={29 9},
  pages={1076-81}
}
OBJECTIVE To investigate the participation of clonotypic MM B cells in the IL-6 network in patients with multiple myeloma. METHODS CD19(+) B cells from 45 patients with multiple myeloma and from 18 healthy donors were sorted and their expression of IL-6, IL-6 receptor (CD126) characterized by flow cytometry, in situ RT-PCR, and ELISA measurement of IL-6 and soluble IL-6R. Expression of CD31 was detected by flow cytometry. RESULTS Interleukin-6 (IL-6) is a pleiotropic cytokine often… CONTINUE READING

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