Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway.

  title={Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway.},
  author={Hyun Chong Shin and N Benbernou and St{\'e}phane Esnault and Moncef Guenounou},
  volume={11 4},
In the present study, the authors compared the interleukin 17 (IL-17 expression of human naive and phenotypically defined memory T cells as well as its regulation by cAMP pathway. Our data showed that IL-17 mRNA was highly expressed in memory human peripheral CD8(+)45RO+T cells and CD4(+)45RO+T cells when peripheral blood mononuclear cells were first stimulated with ionomycin/PMA. IL-17 expression in memory CD8(+)T cells required accessory signals since culture of ionomycin/PMA-activated CD8… CONTINUE READING
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