Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise.

@article{Hameed2003ExpressionOI,
  title={Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise.},
  author={Mahjabeen Hameed and Richard W. Orrell and Matthew Cobbold and Geoffrey Goldspink and Stephen D. R. Harridge},
  journal={The Journal of physiology},
  year={2003},
  volume={547 Pt 1},
  pages={247-54}
}
The mRNA expression of two splice variants of the insulin-like growth factor-I (IGF-I) gene, IGF-IEa and mechano growth factor (MGF), were studied in human skeletal muscle. Subjects (eight young, aged 25-36 years, and seven elderly, aged 70-82 years) completed 10 sets of six repetitions of single legged knee extensor exercise at 80 % of their one repetition maximum. Muscle biopsy samples were obtained from the quadriceps muscle of both the control and exercised legs 2.5 h after completion of… CONTINUE READING
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