Expression of IGF-1, IGF-1 receptor and TGF-beta following balloon angioplasty in atherosclerotic and normal rabbit iliac arteries: an immunocytochemical study.

@article{Grant1999ExpressionOI,
  title={Expression of IGF-1, IGF-1 receptor and TGF-beta following balloon angioplasty in atherosclerotic and normal rabbit iliac arteries: an immunocytochemical study.},
  author={Maria B Grant and T J Wargovich and Donna M Bush and Danny Player and S Baulies Caballero and Marie Foegh and Polyxenie E. Spoerri},
  journal={Regulatory peptides},
  year={1999},
  volume={79 1},
  pages={47-53}
}
Growth factors have been implicated in the pathogenesis of restenosis (myointimal hyperplasia after coronary interventions). In this study, we examined the expression of insulin-like growth factor-I (IGF-1), IGF-1 receptor, and transforming growth factor-beta (TGF-beta) in atherosclerotic and normal rabbit iliac arteries following overstretch balloon angioplasty of the iliac arteries to create a vascular lesion. Animals were sacrificed at 0, 3, 7, 15 and 42 days post angioplasty. The iliac… CONTINUE READING

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