Expression of IGF‐I splice variants in young and old human skeletal muscle after high resistance exercise

@article{Hameed2003ExpressionOI,
  title={Expression of IGF‐I splice variants in young and old human skeletal muscle after high resistance exercise},
  author={Mahjabeen Hameed and Richard W. Orrell and Matthew Cobbold and Geoffrey Goldspink and Stephen D. R. Harridge},
  journal={The Journal of Physiology},
  year={2003},
  volume={547}
}
The mRNA expression of two splice variants of the insulin‐like growth factor‐I (IGF‐I) gene, IGF‐IEa and mechano growth factor (MGF), were studied in human skeletal muscle. Subjects (eight young, aged 25–36 years, and seven elderly, aged 70–82 years) completed 10 sets of six repetitions of single legged knee extensor exercise at 80 % of their one repetition maximum. Muscle biopsy samples were obtained from the quadriceps muscle of both the control and exercised legs 2.5 h after completion of… Expand
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Effects of resistance training on expression of IGF-I splice variants in younger and older men
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Serum IGF-I levels and IGF-I gene splicing in muscle of healthy young males receiving rhGH.
  • M. Aperghis, C. Velloso, +5 authors G. Goldspink
  • Medicine
  • Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
  • 2009
TLDR
Although rhGH administration has an effect on liver IGF-I expression, as shown by increase in circulating IGF-i, muscle IGF- I expression is unaffected in young healthy subjects with normal GH profile, which contrasts with those of a previous study in which GH deficient elderly men showed higher muscle IGF -I 3' splice variant levels following rh GH administration. Expand
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