Expression of ICOS on human melanoma-infiltrating CD4+CD25highFoxp3+ T regulatory cells: implications and impact on tumor-mediated immune suppression.

@article{Strauss2008ExpressionOI,
  title={Expression of ICOS on human melanoma-infiltrating CD4+CD25highFoxp3+ T regulatory cells: implications and impact on tumor-mediated immune suppression.},
  author={Laura Strauss and Christoph Bergmann and Miroslaw J Szczepanski and S. W. Lang and John Munn Kirkwood and Theresa L Whiteside},
  journal={Journal of immunology},
  year={2008},
  volume={180 5},
  pages={
          2967-80
        }
}
OBJECTIVE Interaction of ICOS with its ligand (ICOSL, B7-H2) promotes T cell responses. As CD4+CD25highFoxp3+ naturally occurring T regulatory cells in melanoma patients express ICOS, we investigated the impact of ICOS on naturally occurring T regulatory cell function. METHODS Expression of ICOS and T regulatory (Treg) cell markers was determined on CD4+CD25high T cells in PBMC and tumor-infiltrating lymphocytes from melanoma patients (n=10) and PBMC of normal controls (n=10) by multicolor… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Highly Cited
This paper has 140 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
SHOWING 1-10 OF 69 CITATIONS, ESTIMATED 49% COVERAGE

140 Citations

0102030'10'13'16'19
Citations per Year
Semantic Scholar estimates that this publication has 140 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…