Expression of I-CreI endonuclease generates deletions within the rDNA of Drosophila.

@article{Paredes2009ExpressionOI,
  title={Expression of I-CreI endonuclease generates deletions within the rDNA of Drosophila.},
  author={Silvana Paredes and Keith A Maggert},
  journal={Genetics},
  year={2009},
  volume={181 4},
  pages={
          1661-71
        }
}
The rDNA arrays in Drosophila contain the cis-acting nucleolus organizer regions responsible for forming the nucleolus and the genes for the 28S, 18S, and 5.8S/2S RNA components of the ribosomes and so serve a central role in protein synthesis. Mutations or alterations that affect the nucleolus organizer region have pleiotropic effects on genome regulation and development and may play a role in genomewide phenomena such as aging and cancer. We demonstrate a method to create an allelic series of… CONTINUE READING

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